Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer.

Abstract

Tumor necrosis factor receptor 2 (TNFR2) is expressed both by some cancer cells and by tumor-infiltrating immunosuppressive CD4+FoxP3+ regulatory T cells (Tregs). TNFR2 stimulates the activation and proliferation of Tregs, a major checkpoint of antitumor immune responses, and promotes cancer cell survival and tumor growth. In this issue of Science Signaling, Torrey et al found that dominant antagonistic antibodies against human TNFR2 may be a potential therapy for ovarian cancer patients by simultaneously suppressing Treg activity and inducing the death of the cancer cells.

• Authors: Xin Chen, Joost J Oppenheim
• Journal: Science signaling (Sci Signal) Vol. 10 Issue 462 (01 17 2017) ISSN: 1937-9145 [Electronic] United States
• PMID: 28096506 (Publication Type: Journal Article, Review, Comment)
• Copyright: Copyright © 2017, American Association for the Advancement of Science.

Chemical References

• Oncogene Proteins
• Receptors, Tumor Necrosis Factor, Type II

Topics

• Cell Proliferation
• Female
• Humans
• Oncogene Proteins
• Ovarian Neoplasms
• Receptors, Tumor Necrosis Factor, Type II (antagonists & inhibitors)
• T-Lymphocytes, Regulatory (cytology)