Abstract | BACKGROUND/AIM: MATERIALS AND METHODS: Thirty-five children with autism and 31 healthy subjects were studied. GI problems, sleep disorders, and severity of disorder were assessed. Plasma serotonin was determined using ELISA. RESULTS: There was no significant association between GI problems and autism severity, but a significant positive correlation was seen between different indicators of sleep disorder and severity of autism. Plasma levels of serotonin were significantly higher in autistic children and a significant negative correlation was observed between plasma levels of serotonin and autism severity (r = -0.39, P = 0.02). CONCLUSION: Elevated plasma serotonin in autistic children and its negative correlation with disease severity may indicate involvement of the neurotransmitter in the neurophysiologic mechanism of autism.
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Authors | Sorayya Kheirouri, Parinaz Kalejahi, Seyyed Gholamreza Noorazar |
Journal | Turkish journal of medical sciences
(Turk J Med Sci)
Vol. 46
Issue 6
Pg. 1765-1772
(Dec 20 2016)
ISSN: 1300-0144 [Print] Turkey |
PMID | 28081325
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Autistic Disorder
- Child
- Gastrointestinal Diseases
- Humans
- Serotonin
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