Gold nanorod embedded large-pore mesoporous organosilica nanospheres for gene and photothermal cooperative therapy of triple negative breast cancer.
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| Abstract |
To date, clinicians still lack an effective strategy to treat triple negative breast cancer (TNBC). In this work, we design for the first time a gold nanorod embedded large-pore mesoporous organosilica (GNR@LPMO) nanoplatform for gene and photothermal cooperative therapy of TNBC. The synthesized GNR@LPMOs possess a uniform size (175 nm), high surface area (631 m2 g-1), large pore size, excellent photothermal efficiency, and good biocompatibility. Thanks to the large-pore mesoporous organosilica layer, the GNR@LPMO nanoplatforms display much higher loading capacity of siRNA compared with traditional liposome and bare gold nanorods. Thus, functional siRNA can be efficiently delivered into TNBC cells by GNR@LPMOs, causing much higher cell apoptosis through knocking down the PLK1 proteins. By combining the effective gene delivery and photothermal abilities, the GNR@LPMO nanoplatforms are further used for gene and photothermal cooperative therapy of TNBC, which induce a 15 fold higher mice tumor inhibition rate than sole therapy modality, indicating the potential clinical use of this novel nanoplatform in treating TNBC.
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| Authors | Qianqian Ni, Zhaogang Teng, Meng Dang, Ying Tian, Yunlei Zhang, Peng Huang, Xiaodan Su, Nan Lu, Zhenlu Yang, Wei Tian, Shouju Wang, Wenfei Liu, Yuxia Tang, Guangming Lu, Longjiang Zhang |
| Journal | Nanoscale (Nanoscale) Vol. 9 Issue 4 Pg. 1466-1474 (Jan 26 2017) ISSN: 2040-3372 [Electronic] England |
| PMID | 28066849 (Publication Type: Journal Article) |
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