Long-term outcomes of peripheral blood stem cell transplantation for 38 patients with peripheral T-cell lymphoma.

Abstract

OBJECTIVE:

In this study, to investigate clinical characteristics, response, outcome, and prognosis of peripheral blood stem cell transplantation (PBSCT) for patients with peripheral T-cell lymphoma (PTCL).

METHODS:

This study retrospectively analyzed the efficacy of PBSCT in 38 patients with PTCL. Kaplan-Meier methods were used in survival analysis, and the Cox regression model was applied in multivariate analysis. There were ten clinical parameters were analyzed.

RESULTS:

The 2-year overall survival (OS) was 46%, and the 5-year OS was 34% after a median follow-up of 40 months. The patients who received allogeneic PBSCT (allo-PBSCT) had a higher nonrelapse mortality than autologous PBSCT (auto-PBSCT), but they could achieve a longer-term disease-free survival in the former, which OS could achieve 40%. Survival analysis with Kaplan-Meier method showed the pretransplant disease status, B symptoms, serum lactate dehydrogenase (LDH) in early (>275 U/L), Eastern Cooperative Oncology Group (ECOG) score (>1), prognostic index for PTCL score (>2) were all prognostic factors for posttransplant OS. Pretransplant disease status is the only prognostic factor for allo-PBSCT.

CONCLUSION:

The key was to reducing transplant-related mortality of allo-PBSCT by reduced-intensity conditioning. Factors such as level of early serum LDH, extranodal involvement, B symptoms, ECOG score, Ann Arbor stage, and pretransplant disease status were all related to the prognosis of patients treated with PBSCT. Allo-PBSCT maybe suggested as the first line therapy for late-stage PTCL patients who could reach treatment remission before transplantation.

• Authors: Jian Bo, Yu Zhao, Songsong Zhang, Wenrong Hua, Shuhong Wang, Chunji Gao, Quanshun Wang, Honghua Li, Li Yu
• Journal: Journal of cancer research and therapeutics (J Cancer Res Ther) 2016 Jul-Sep Vol. 12 Issue 3 Pg. 1189-1197 ISSN: 1998-4138 [Electronic] India
• PMID: 28054534 (Publication Type: Journal Article)

Chemical References

• Biomarkers

Topics

• Adolescent
• Adult
• Biomarkers
• Cause of Death
• Child
• Combined Modality Therapy
• Female
• Follow-Up Studies
• Humans
• Lymphoma, T-Cell, Peripheral (diagnosis, mortality, therapy)
• Middle Aged
• Neoplasm Staging
• Peripheral Blood Stem Cell Transplantation (adverse effects, methods)
• Prognosis
• Survival Analysis
• Transplantation Conditioning
• Transplantation, Autologous
• Transplantation, Homologous
• Treatment Outcome
• Young Adult