[Comparison of isosorbide dinitrate and nifedipine in the treatment of variant angina pectoris. Randomized study].

Abstract

The effects of isosorbide dinitrate single dose 120 mg daily and nifedipine 20 mg twice daily were studied in 17 patients with variant angina pectoris due to coronary artery spasm. After a placebo phase the patients were randomized to treatment with either isosorbide dinitrate or nifedipine. After six weeks the patients were crossovered for another six weeks period of treatment. There was significant decrease of number of angina attacks during both treatment regimens. Using 24 hours Holter monitoring we also proved significant decrease of number of ST segment elevation or depression, either symptomatic or asymptomatic. There was increase of performed work during exercise tests after both treatment periods. The efficacy of Isoket 120 mg and Adalat Retard 2 x 20 mg daily in the treatment of patients with active variant angina pectoris was comparable in our study. 3 patients suffered untolerable headache during isosorbide dinitrate phase and had to terminate treatment after first day only.

• Authors: M Aschermann, J Bultas, D Karetová, F Kölbel, D Simper, M Kozáková
• Journal: Casopis lekaru ceskych (Cas Lek Cesk) Vol. 128 Issue 37 Pg. 1178-81 (Sep 08 1989) ISSN: 0008-7335 [Print] Czech Republic
• Vernacular Title: Srovnání isosorbid dinitrátu a nifedipinu v lécbĕ variantní anginy pectoris. Randomizovaná studie.
• PMID: 2805034 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Nifedipine
• Isosorbide Dinitrate

Topics

• Adult
• Angina Pectoris, Variant (drug therapy, physiopathology)
• Double-Blind Method
• Electrocardiography, Ambulatory
• Female
• Humans
• Isosorbide Dinitrate (therapeutic use)
• Male
• Middle Aged
• Nifedipine (therapeutic use)
• Random Allocation