[Characteristics of the action of cisplatin and cycloplatam on the rat kidney].

Abstract

On the 5th day after intraperitoneal injection of cisplatin the rats developed renal insufficiency. The concentration of creatinine and urea in blood serum increased 9-fold, the glomerular filtration rate decreased 7.7-fold, the weight of kidney increased by 44%. The content of tissue sodium was found to increase, while that of K to decrease. The intraperitoneal injections of cycloplatam (up to 25 mg/kg) induced in rats no renal insufficiency, the kidney weight and the ion and water content in the tissue did not change. In the experiments with cisplatin the Pt level in kidney reached 59.1 +/- 3.05 micrograms/g dry substance, after the injection of cycloplatam 25 mg/kg it was 104.9 +/- 2.95. No nephrotoxic action of cycloplatam may be due to the presence in the molecule of the cyclopentyl substitute.

• Authors: Iu V Natochin, L V Reznik, V K Brovtsyn, V B Ivanov, E M Miazina, P A Chel'tsov, E I Shakhmatova
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 108 Issue 7 Pg. 52-4 (Jul 1989) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Osobennosti deĭstviia tsisplatina i tsikloplatama na pochku krysi.
• PMID: 2804301 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Organoplatinum Compounds
• cycloplatam
• Cisplatin

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Cisplatin (administration & dosage, pharmacology)
• Female
• Glomerular Filtration Rate (drug effects)
• Injections, Intraperitoneal
• Kidney (drug effects)
• Kidney Diseases (chemically induced)
• Organoplatinum Compounds (administration & dosage, pharmacology)
• Rats
• Rats, Inbred Strains