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6-Mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity.

Abstract
We assess toxicity related to 6-mercaptopurine in the treatment of inflammatory bowel disease by reporting our experience with 396 patients (120 patients with ulcerative colitis, 276 with Crohn disease) observed over 18 years. Follow-up data for a mean period of 60.3 months were obtained for 90% of the patients. Toxicity directly induced by 6-mercaptopurine included pancreatitis in 13 patients (3.3%), bone marrow depression in 8 (2%), allergic reactions in 8 (2%), and drug hepatitis in 1 (0.3%). These complications were reversible in all cases with no mortality. Most cases of marrow depression occurred earlier in our experience, when the initial drug doses used were higher. Infectious complications were seen in 29 patients (7.4%), of which 7 (1.8%) were severe, including one instance of herpes zoster encephalitis. All infections were reversible with no deaths. Twelve neoplasms (3.1%) were observed, but only 1 (0.3%), a diffuse histiocytic lymphoma of the brain, had a probable association with the use of 6-mercaptopurine. Our data, showing a low incidence of toxicity in 396 patients, coupled with the previously demonstrated efficacy of 6-mercaptopurine in the treatment of inflammatory bowel disease, indicate that the drug is a reasonable alternative in the management of patients with intractable inflammatory bowel disease.
AuthorsD H Present, S J Meltzer, M P Krumholz, A Wolke, B I Korelitz
JournalAnnals of internal medicine (Ann Intern Med) Vol. 111 Issue 8 Pg. 641-9 (Oct 15 1989) ISSN: 0003-4819 [Print] UNITED STATES
PMID2802419 (Publication Type: Journal Article)
Chemical References
  • 6-Mercaptopurine
Topics
  • 6-Mercaptopurine (adverse effects, therapeutic use)
  • Adolescent
  • Adult
  • Aged
  • Bone Marrow Diseases (chemically induced)
  • Child
  • Colitis, Ulcerative (drug therapy)
  • Crohn Disease (drug therapy)
  • Double-Blind Method
  • Drug Hypersensitivity (etiology)
  • Drug-Induced Liver Injury (etiology)
  • Female
  • Follow-Up Studies
  • Humans
  • Infection (epidemiology)
  • Male
  • Middle Aged
  • Neoplasms (epidemiology)
  • Pancreatitis (chemically induced)
  • Pregnancy
  • Time Factors

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