Quantitative immunoglobulins and IgG subclasses in patients with corticosteroid-dependent reversible airway obstruction.

Abstract

Six of 12 patients with corticosteroid-dependent bronchial asthma and recurrent sinopulmonary infections were found to have significant abnormalities in quantitative immunoglobulins and/or IgG subclasses. Five patients had a combined quantitative immunoglobulin and IgG subclass deficiency and one patient had an isolated IgG deficiency. Combined IgG subclass deficiencies were observed in two patients, both with deficiencies of IgG2 and IgG3. The most common IgG subclass deficiencies were of IgG2 and IgG3, which were found in three patients each.

• Authors: W B Klaustermeyer, S C Wong, J J Schoettler, M E Gianos, D C Heiner
• Journal: Annals of allergy (Ann Allergy) Vol. 63 Issue 4 Pg. 327-30 (Oct 1989) ISSN: 0003-4738 [Print] United States
• PMID: 2802270 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Immunoglobulin G
• Immunoglobulins

Topics

• Adrenal Cortex Hormones (pharmacology)
• Aged
• Airway Obstruction (physiopathology)
• Female
• Humans
• Immunoglobulin G (analysis, classification)
• Immunoglobulins (analysis, classification)
• Male
• Middle Aged
• Respiratory Function Tests