[Studies on synthesis of baogongteng A--a new myotic agent].

Abstract

Baogongteng A, isolated from Erycibe obtusifolia Benth., is a new tropane alkaloid used for treating glaucoma. Using synthetic 6 beta-acetoxy-tropinone as starting material, racemic Baogongteng A(8) was synthesized. Synthetic Baogongteng A also shows myotic activities in rabbits, but the potency is half of that of the natural product.

• Authors: Z Xiang, J E Zhou, Z N Chen, L P Wang, H N Wang, T R Yao, J X Xie, G Y Xu, D N Yi
• Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 24 Issue 2 Pg. 105-9 ( 1989) ISSN: 0513-4870 [Print] China
• PMID: 2801130 (Publication Type: Journal Article)

Chemical References

• Bridged Bicyclo Compounds
• Bridged Bicyclo Compounds, Heterocyclic
• Bridged-Ring Compounds
• Miotics
• Tropanes
• bao gong teng A

Topics

• Bridged Bicyclo Compounds (chemical synthesis)
• Bridged Bicyclo Compounds, Heterocyclic
• Bridged-Ring Compounds (chemical synthesis)
• Miotics (chemical synthesis)
• Tropanes