Effects of N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) on shock elicited fighting in rats.

Abstract

Rats were tested for shock elicited fighting under various doses of N,N-dimethyltryptamine (0.12, 0.25, 0.50, 1.0, 4.0, 8.0 mg/kg) and 5-methoxy-N,N-dimethyltryptamine (0.06, 0.12, 0.5, 2.0 mg/kg). Both drugs produced an inhibition of fighting at higher doses but no significant effects at lower doses. The effects of these drugs on shock elicited fighting, as well as on other behaviors, thus differ from those of another indole hallucinogen, d-lysergic acid diethylamide, and are discussed in relation to their effects on single unit activity of the raphe-serotonin system and their interaction with other neurotransmitter systems.

• Authors: J K Walters, M H Sheard, M Davis
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 9 Issue 1 Pg. 87-90 (Jul 1978) ISSN: 0091-3057 [Print] United States
• PMID: 279938 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Receptors, Serotonin
• Tryptamines
• N,N-Dimethyltryptamine

Topics

• Aggression (drug effects)
• Animals
• Dose-Response Relationship, Drug
• Electroshock
• Humans
• Male
• N,N-Dimethyltryptamine (analogs & derivatives, pharmacology)
• Raphe Nuclei (drug effects)
• Rats
• Receptors, Serotonin (drug effects)
• Tryptamines (pharmacology)