The United Kingdom Diabetic Retinopathy Electronic Medical Record Users Group, Report 1: baseline characteristics and visual acuity outcomes in eyes treated with intravitreal injections of ranibizumab for diabetic macular oedema.

Abstract

AIMS:

To describe baseline characteristics and visual outcome for eyes treated with ranibizumab for diabetic macular oedema (DMO) from a multicentre database.

METHODS:

Structured clinical data were anonymised and extracted from an electronic medical record from 19 participating UK centres: age at first injection, ETDRS visual acuity (VA), number of injections, ETDRS diabetic retinopathy (DR) and maculopathy grade at baseline and visits. The main outcomes were change in mean VA from baseline, number of injections and clinic visits and characteristics affecting VA change and DR grade.

RESULTS:

Data from 12 989 clinic visits was collated from baseline and follow-up for 3103 eyes. Mean age at first treatment was 66 years. Mean VA (letters) for eyes followed at least 2 years was 51.1 (SD=19.3) at baseline, 54.2 (SD: 18.6) and 52.5 (SD: 19.4) at 1 and 2 years, respectively. Mean visual gain was five letters. The proportion of eyes with VA of 72 letters or better was 25% (baseline) and 33% (1 year) for treatment naïve eyes. Eyes followed for at least 6 months received a mean of 3.3 injections over a mean of 6.9 outpatient visits in 1 year.

CONCLUSIONS:

In a large cohort of eyes with DMO treated with ranibizumab injections in the UK, 33% of patients achieved better than or equal to 6/12 in the treated eye at 12 months compared with 25% at baseline. The mean visual gain was five letters. Eyes with excellent VA at baseline maintain good vision at 18 months.

• Authors: Catherine Egan, Haogang Zhu, Aaron Lee, Dawn Sim, Danny Mitry, Clare Bailey, Robert Johnston, Usha Chakravarthy, Alastair Denniston, Adnan Tufail, Rehna Khan, Sajjad Mahmood, Geeta Menon, Toks Akerele, Louise Downey, Martin McKibbin, Atul Varma, Aires Lobo, Elizabeth Wilkinson, Alan Fitt, Christopher Brand, Marie Tsaloumas, Kaveri Mandal, Vineeth Kumar, Salim Natha, David Crabb, UK AMD and DR EMR Users Group
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 101 Issue 1 Pg. 75-80 (Jan 2017) ISSN: 1468-2079 [Electronic] England
• PMID: 27965262 (Publication Type: Journal Article)
• Copyright: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Chemical References

• Angiogenesis Inhibitors
• Ranibizumab

Topics

• Aged
• Angiogenesis Inhibitors (therapeutic use)
• Diabetic Retinopathy (drug therapy, physiopathology)
• Female
• Humans
• Intravitreal Injections
• Macular Edema (drug therapy, physiopathology)
• Male
• Middle Aged
• Ranibizumab (administration & dosage)
• Reading
• Visual Acuity (physiology)