[Double minute chromosomes (DMs) in a case of acute myelomonocytic leukemia].

Abstract

A 71-year old male was admitted to our hospital because of general malaise and fever. Peripheral blood showed Hb 8.1 g/dl, platelet 7.0 X 10(4)/microliters, and WBC 18.100/microliters with 64% leukemic cells. Bone marrow showed normocellularity with 73.4% leukemic cells. They were positive for peroxidase and alpha-naphthyl butyrate esterase stainings. Serum and urine lysozyme levels were elevated. He was diagnosed as having acute myelomonocytic leukemia (M 4 in FAB classification). Chromosome analysis of bone marrow cells showed 45, XY, -17, t (9; 17) (q22; p13) and double minute chromosomes (DMs) were observed in the 50 cells analyzed. A complete remission (CR) was obtained by DCMP regimen, but he relapsed as acute monocytic leukemia (M 5 b in FAB classification) and died 5 months after diagnosis. DMs appear to be rare in acute leukemia and the clinical and etiologic implications of DMs are discussed.

• Authors: T Takesako, S Murakami, H Haruyama, N Oku, N Takeda, K Itoh, N Fujita, S Nakanish, C Shimazaki, T Isemura
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 30 Issue 6 Pg. 882-6 (Jun 1989) ISSN: 0485-1439 [Print] Japan
• PMID: 2795899 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Aged
• Chromosome Aberrations
• Chromosome Banding
• Humans
• Karyotyping
• Leukemia, Myelomonocytic, Acute (genetics)
• Male