HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Delayed postoperative neurological deterioration from prolonged sodium nitroprusside administration. Case report.

Abstract
Sodium nitroprusside is commonly used for the induction of hypotension during neurosurgical procedures. Its toxicity stems from hemodynamic compromise as well as from its metabolites, especially the formation of cyanide. A patient is described who underwent craniotomy for hypertensive intracerebral hemorrhage. He gradually recovered following the operation, but needed continued administration of sodium nitroprusside for control of hypertension. On the 7th postoperative day, he deteriorated into coma with evidence of severe edema and herniation on the computerized tomography scan. Cessation of sodium nitroprusside and treatment for cyanide poisoning resulted in resolution of his symptoms within hours. The potential toxicity of sodium nitroprusside, measures to prevent toxicity, and therapeutic steps are discussed.
AuthorsZ Ram, R Spiegelman, G Findler, M Hadani
JournalJournal of neurosurgery (J Neurosurg) Vol. 71 Issue 4 Pg. 605-7 (Oct 1989) ISSN: 0022-3085 [Print] United States
PMID2795179 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Cyanides
  • Ferricyanides
  • Nitroprusside
  • Propranolol
Topics
  • Brain Edema (chemically induced, diagnostic imaging)
  • Cerebral Hemorrhage (etiology, surgery)
  • Coma (chemically induced)
  • Craniotomy
  • Cyanides (poisoning)
  • Ferricyanides (adverse effects)
  • Hematoma (etiology, surgery)
  • Humans
  • Hypertension (complications, drug therapy)
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Nitroprusside (administration & dosage, adverse effects, therapeutic use)
  • Propranolol (therapeutic use)
  • Radiography

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: