Prospective observation of filtration blebs in high-risk eyes with limbal-based conjunctival flap.

Abstract

OBJECTIVE:

To evaluate time-dependent changes in filtering bleb parameters using 3-dimensional anterior segment optical coherence tomography (3-D AS-OCT) in high-risk eyes after a limbal-based trabeculectomy procedure.

DESIGN:

Prospective, observational study.

PARTICIPANTS:

Twenty-three patients who underwent uncombined limbal-based trabeculectomy surgery and who also had a history of prior intraocular surgery.

METHODS:

Of 23 eyes, 15 eyes were followed for 1 year without additional glaucoma surgeries, and their bleb parameters were measured 0.5, 3, 6, and 12 months after the trabeculectomy using 3-dimensional anterior segment optical coherence tomography. The correlations of these parameters to other clinical data were investigated.

RESULTS:

Statistical analysis showed significant changes in the bleb wall thickness (0.7 ± 0.4 mm vs 0.4 ± 0.2 mm; p = 0.007) and fluid cavity height (0.3 ± 0.2 mm vs 0.7 ± 0.4 mm; p = 0.005) between 0.5 and 3 months only. The width of the filtration openings at 0.5 months after trabeculectomy (2.1 ± 1.0 mm) was significantly associated with the intraocular pressure at 12 months (15.1 ± 5.7 mm Hg; R2 = 0.37, t = -2.65, and p = 0.021).

CONCLUSIONS:

The width of the filtration opening in the early stage may be a prognostic factor for long-term intraocular pressure control.

• Authors: Momoka Matsumoto, Toshihiro Inoue, Sachi Kojima, Kei-Ichi Nakashima, Ayako Fukushima, Hidenobu Tanihara
• Journal: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie (Can J Ophthalmol) Vol. 51 Issue 6 Pg. 431-437 (Dec 2016) ISSN: 1715-3360 [Electronic] England
• PMID: 27938954 (Publication Type: Journal Article, Observational Study)
• Copyright: Copyright © 2016 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

Topics

• Aged
• Conjunctiva (diagnostic imaging, surgery)
• Female
• Glaucoma (diagnostic imaging, surgery)
• Humans
• Imaging, Three-Dimensional
• Intraocular Pressure (physiology)
• Limbus Corneae (diagnostic imaging, surgery)
• Male
• Middle Aged
• Prospective Studies
• Surgical Flaps
• Surgical Stomas
• Tomography, Optical Coherence
• Tonometry, Ocular
• Trabeculectomy