A new immunomodulator, FR-901235.

FR-901235 is a new type of immunoactive substance produced by an imperfect fungus, Paecilomyces carneus F-4882. The mitogen-induced lymphocyte proliferation which had been suppressed by addition of immunosuppressive factor, was restored to a normal level by the addition of FR-901235. Furthermore, the subsequent administration of FR-901235 partially restored the impaired delayed-type hypersensitivity to sheep red blood cells in tumor-bearing mice.
AuthorsT Shibata, M Nishikawa, Y Tsurumi, S Takase, H Terano, M Kohsaka
JournalThe Journal of antibiotics (J Antibiot (Tokyo)) Vol. 42 Issue 9 Pg. 1356-61 (Sep 1989) ISSN: 0021-8820 [Print] JAPAN
PMID2793590 (Publication Type: Journal Article)
Chemical References
  • Adjuvants, Immunologic
  • Phenalenes
  • Polycyclic Compounds
  • FR 901235
  • Adjuvants, Immunologic (isolation & purification, pharmacology)
  • Animals
  • Chemical Phenomena
  • Chemistry
  • Female
  • In Vitro Techniques
  • Lymphocyte Activation (drug effects)
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred ICR
  • Phenalenes
  • Polycyclic Compounds (isolation & purification, pharmacology)
  • Spleen (drug effects)

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