A phase II study of spirogermanium in patients with advanced malignant lymphoma.
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| Abstract |
Spirogermanium was given as a 90 minute infusion to 47 eligible patients with refractory Hodgkin's (9 patients) or non-Hodgkin's lymphoma (38 patients). The schedule was 80 mg/m2 three times a week for the first two weeks and 100 mg/m2, 3 times a week, for the two subsequent weeks. In case of response or stable disease, the treatment was continued with biweekly infusions of 100 mg/m2 until tumor progression. In 64% of cases, three or more combinations had been previously administered; 66% of patients presented an extra-lymphatic spread of disease. Two patients with Hodgkin's disease showed a partial response of 11 and 23 weeks and two patients with non-Hodgkin's lymphoma achieved a complete response of 12 and 24 weeks. Overall, 14 patients showed a tumor progression within the first month of treatment. The main toxicity was neurological, with dizziness and lethargy during the infusion in 50% of cases. Hematologic toxicity was almost absent. Spirogermanium is ineffective in heavily pretreated patients with non-Hodgkin's lymphoma. The confirmed lack of activity in patients with refractory malignant lymphoma and the need of repeated and prolonged infusions definitely discourage the clinical use of the drug.
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| Authors | C Sessa, W ten Bokkel Huinik, M Clavel, L M Lev, R A Joss, J Renard, F Cavalli |
| Journal | Investigational new drugs (Invest New Drugs) Vol. 7 Issue 2-3 Pg. 219-22 (Jul 1989) ISSN: 0167-6997 [Print] United States |
| PMID | 2793376 (Publication Type: Journal Article) |
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