Ewing Sarcoma of the Bone With EWS/FLI1 Translocation After Successful Treatment of Primary Osteosarcoma.

Abstract

Although prognosis in patients with localized osteosarcoma has been dramatically improved by the introduction of multiple chemotherapy agents known as combination chemotherapy, there is growing concern about the development of secondary malignant neoplasms. We report the case of a 13-year-old girl in whom the diagnosis of Ewing sarcoma of bone localized on the shaft of left femur was made 2 years after successful treatment without radiotherapy for osteosarcoma of right proximal femur. EWS-FLI1 fusion gene was detected by reverse transcriptase-polymerase chain reaction. To our knowledge, this is the first case with Ewing sarcoma of the bone as a secondary malignant neoplasm developed in osteosarcoma survivor. We collected 15 cases, included this case, with secondary Ewing sarcoma family of tumor by utilizing the PubMed search and might consider the causes of this secondary cancer.

• Authors: Noriko Yodoya, Shotaro Iwamoto, Akihiko Matsumine, Eiichi Azuma, Hidemi Toyoda, Yoshihiro Miura, Kaname Nakatani, Hiroshi Imai, Masahiro Hirayama, Yoshihiro Komada
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 39 Issue 1 Pg. 6-9 (01 2017) ISSN: 1536-3678 [Electronic] United States
• PMID: 27918348 (Publication Type: Case Reports, Journal Article)

Chemical References

• EWS-FLI fusion protein
• Oncogene Proteins, Fusion
• Proto-Oncogene Protein c-fli-1
• RNA-Binding Protein EWS
• Vincristine
• Etoposide
• Doxorubicin
• Cyclophosphamide
• Carboplatin
• pirarubicin
• Cisplatin
• Ifosfamide
• Methotrexate

Topics

• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Carboplatin (administration & dosage, adverse effects)
• Child
• Cisplatin (administration & dosage, adverse effects)
• Combined Modality Therapy
• Cyclophosphamide (administration & dosage)
• Doxorubicin (administration & dosage, adverse effects, analogs & derivatives)
• Etoposide (administration & dosage, adverse effects)
• Female
• Femoral Neoplasms (drug therapy, genetics, surgery)
• Humans
• Ifosfamide (administration & dosage, adverse effects)
• Limb Salvage
• Methotrexate (administration & dosage, adverse effects)
• Neoplasms, Second Primary (drug therapy, genetics, surgery)
• Oncogene Proteins, Fusion (genetics)
• Osteosarcoma (drug therapy, surgery)
• Proto-Oncogene Protein c-fli-1 (genetics)
• RNA-Binding Protein EWS (genetics)
• Remission Induction
• Sarcoma, Ewing (drug therapy, genetics, surgery)
• Vincristine (administration & dosage)