[Anti-allergic properties of pipethiaden--a new preventive agent for migraine].

Abstract

Pipethiadene, a prophylactic of vasomotoric headaches of the series of 4,9-dihydrothieno(2,3-c)-2-benzothiepine derivatives, shows a peripheralpharmacological profile of an antiallergic agent. The experiments in rats showed a high antianaphylactic effect of pipethiadene in the passive cutaneous anaphylaxis (PCA) test. Pipethiadene also exerted intensive antianaphylactoid action in rats on the liberator of histamine, compound 48/80, on dextran, and in the use of a combination of ovalbumin with indomethacin. In comparative pharmacological experiments with pizotifen and cyproheptadine an attempt was made to estimate the relative role of histamine and 5-hydroxytryptamine 5-HT) mediators in the employed experimental procedures in rats.

• Authors: H Frycová, J Metys
• Journal: Ceskoslovenska farmacie (Cesk Farm) Vol. 38 Issue 6 Pg. 264-8 (Jul 1989) ISSN: 0009-0530 [Print] Czech Republic
• Vernacular Title: Antialergické vlastnosti pipethiadenu--nového profylaktika migrény.
• PMID: 2790993 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Piperidines
• Pizotyline
• Cyproheptadine
• pipethiaden

Topics

• Anaphylaxis (chemically induced, prevention & control)
• Animals
• Cyproheptadine (therapeutic use)
• Female
• Guinea Pigs
• Mice
• Migraine Disorders (prevention & control)
• Passive Cutaneous Anaphylaxis (drug effects)
• Piperidines (therapeutic use)
• Pizotyline (therapeutic use)
• Rats