Fatal Hemorrhagic Gastrointestinal Angioectasia after Bone Marrow Transplantation for Dyskeratosis Congenita.

Abstract

Dyskeratosis congenita (DC) is a rare inherited disease in which the telomere complex cannot be maintained. Shortened telomeres can cause a number of clinical conditions. We herein report a case of unrelated bone marrow transplantation due to aplastic anemia associated with DC. The patient died of uncontrollable refractory intestinal bleeding. Three cases of DC with life-threatening hemorrhaging after transplantation have been reported; however, the bleeding origin could not be determined. Our case is the only patient in which a gastrointestinal bleeding point, jejunal multiple angioectasia, was determined.

• Authors: Jin Imai, Takayoshi Suzuki, Marie Yoshikawa, Makiko Dekiden, Hirohiko Nakae, Fumio Nakahara, Shingo Tsuda, Hajime Mizukami, Jun Koike, Muneki Igarashi, Hiromasa Yabe, Tetsuya Mine
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) 2016 Vol. 55 Issue 23 Pg. 3441-3444 ISSN: 1349-7235 [Electronic] Japan
• PMID: 27904106 (Publication Type: Case Reports, Journal Article)

Topics

• Anemia, Aplastic (etiology, therapy)
• Bone Marrow Transplantation (adverse effects)
• Dilatation, Pathologic (etiology)
• Dyskeratosis Congenita (complications)
• Female
• Gastrointestinal Hemorrhage (etiology)
• Humans
• Young Adult