[The hyper IgE syndrome (Buckley syndrome)].

Abstract

An exceptional case is reported of hyper IgE syndrome and membranoproliferative glomerulonephritis with onset in 1964. Renal disease, symptoms of hyper IgE syndrome and level of serum IgE were improved by a long-term cyclosporine treatment (3/5 mg/kg/day) with a follow-up of 4 years. The characteristics of the hyper IgE syndrome, described by Buckley in 1972 are given and the respective roles of IgE-BF, IL4 and interferon in the mechanism of increase in serum IgE is discussed.

• Authors: J Laurent, G Rostoker, G Lagrue
• Journal: Allergie et immunologie (Allerg Immunol (Paris)) Vol. 21 Issue 7 Pg. 268-9, 272 (Sep 1989) ISSN: 0397-9148 [Print] France
• Vernacular Title: Le syndrome hyper IgE (syndrome de Buckley).
• PMID: 2789672 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Cyclosporins
• Lymphokines
• Prostatic Secretory Proteins
• beta-microseminoprotein
• immunoglobulin-binding factors
• Interleukin-4
• Immunoglobulin E

Topics

• Cyclosporins (therapeutic use)
• Glomerulonephritis, Membranous (immunology)
• Humans
• Hypergammaglobulinemia (immunology)
• Immunoglobulin E (immunology)
• Interleukin-4 (physiology)
• Lymphokines (physiology)
• Prostatic Secretory Proteins