Generalized granulomatous dermatitis following Mycobacterium w (Mw) immunotherapy in lepromatous leprosy.

Abstract

Mycobacterium w (Mw) vaccine is a heat-killed suspension derived from a nonpathogenic, cultivable, atypical mycobacterium named Mycobacterium indicus pranii. Mw immunotherapy has been reported to be efficacious as an adjunct to multidrug therapy multibacillary regimen in leprosy patients with high bacillary index. Cutaneous reactions are predominant adverse effects associated with the administration of vaccines. Cutaneous adverse effects ascribed to Mw vaccine are generally limited to the site of injection. We herein describe two cases of lepromatous leprosy who developed an unusual generalized cutaneous reaction following Mw immunotherapy. A high index of suspicion is needed to identify such manifestations in leprosy cases to avoid misdiagnosis of a relapse or a reaction and for appropriate treatment.

• Authors: Geeti Khullar, Tarun Narang, Uma Nahar Saikia, Sunil Dogra
• Journal: Dermatologic therapy (Dermatol Ther) Vol. 30 Issue 2 (Mar 2017) ISSN: 1529-8019 [Electronic] United States
• PMID: 27891733 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2016 Wiley Periodicals, Inc.

Chemical References

• Bacterial Vaccines
• Mycobacterium w vaccine

Topics

• Adult
• Bacterial Vaccines (adverse effects)
• Biopsy
• Dermatitis (diagnosis, microbiology)
• Granuloma (diagnosis, microbiology)
• Humans
• Immunotherapy (adverse effects, methods)
• Leprosy, Lepromatous (diagnosis, microbiology, therapy)
• Male
• Mycobacterium Infections, Nontuberculous (diagnosis, microbiology)
• Skin (microbiology, pathology)
• Skin Diseases, Bacterial (diagnosis, microbiology)
• Treatment Outcome
• Young Adult