HLA-Bw60 increases susceptibility to ankylosing spondylitis in HLA-B27+ patients.

Abstract

We examined the distribution of non-B27 alleles of the HLA-B locus among B27+ patients with ankylosing spondylitis (AS), to detect any additional HLA-B locus allele(s) that may act in conjunction with B27 to increase susceptibility to AS. HLA-Bw60 (or B40 when the Bw60,61 split of B40 was not typed for) was shown to be increased among B27+ AS patients in each of 5 independent data sets. This increase was statistically significant in 4 of the 5 data sets studied, and the overall significance was P less than 0.00001. Susceptibility to AS in B27+ individuals was further increased by a factor of approximately 3 when Bw60 was also present. The distribution of HLA-A alleles on the B27-bearing haplotypes in AS patients was not significantly different from that in normal controls. On the other hand, the distribution of HLA-A alleles on Bw60-bearing haplotypes was significantly different from the distribution of A alleles on Bw60 haplotypes in the general population (P less than 0.0005). Bw60 was not increased in B27- patients with AS. A dominant mode of inheritance generally fits AS; however, our sib pair analysis indicates that the B27,Bw60 disease subgroup follows a more recessive mode of inheritance.

• Authors: W P Robinson, S M van der Linden, M A Khan, H U Rentsch, A Cats, A Russell, G Thomson
• Journal: Arthritis and rheumatism (Arthritis Rheum) Vol. 32 Issue 9 Pg. 1135-41 (Sep 1989) ISSN: 0004-3591 [Print] United States
• PMID: 2789045 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• HLA-B Antigens
• HLA-B27 Antigen
• HLA-B60 antigen

Topics

• Alleles
• Canada
• Disease Susceptibility
• Genotype
• HLA-B Antigens (genetics)
• HLA-B27 Antigen
• Haplotypes
• Humans
• Netherlands
• Norway
• Phenotype
• Spondylitis, Ankylosing (genetics)
• Switzerland
• United States