[Hematopoietic precursor cells in Wistar rats with acute myeloblastic leukemia].

Abstract

The studies were performed on Wistar rats with acute myeloblastic leukemia induced by a prolonged administration of tritiated water (370 MBq/kg/day-1; an absorbed dose--25.3 Gy) and by repeated pyrogenal injections. A reduction of the pool of polypotent hemopoietic cells (CFUs) with a simultaneous increase of their proliferative activity and a decline of their ability to self-supporting were observed in the leukemia-bearing animals. Populations of CFUdc in DC and of CFUc were reduced in all cases; their colony-forming ability was also found to decrease. All animals with leukemia showed a lowered amount of CFU-BL in the bone marrow and of CFU-TL in the thymus, although the content of these cells in the peripheral blood remained unchanged.

• Authors: K N Muksinova, L D Murzina, E N Kirillova, V S Revina
• Journal: Eksperimental'naia onkologiia (Eksp Onkol) Vol. 11 Issue 3 Pg. 29-32 ( 1989) ISSN: 0204-3564 [Print] Ukraine
• Vernacular Title: Krovetvornye kletki-predshestvenniki u krys porody Wistar s ostrym mieloblastnym leĭkozom.
• PMID: 2787740 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Lipopolysaccharides
• Pyrogens
• pyrogenal
• Water
• Tritium
• tritium oxide

Topics

• Animals
• B-Lymphocytes (drug effects, pathology, radiation effects)
• Bone Marrow (drug effects, pathology, radiation effects)
• Colony-Forming Units Assay
• Granulocytes (drug effects, pathology, radiation effects)
• Hematopoietic Stem Cells (drug effects, pathology, radiation effects)
• Leukemia, Myeloid, Acute (etiology, pathology)
• Leukemia, Radiation-Induced (etiology, pathology)
• Lipopolysaccharides
• Monocytes (drug effects, pathology, radiation effects)
• Pyrogens
• Rats
• Rats, Inbred Strains
• T-Lymphocytes (drug effects, pathology, radiation effects)
• Time Factors
• Tritium
• Water