Vascular-targeted photodynamic therapy of gastric antral vascular ectasia (GAVE).

Abstract

BACKGROUND AND STUDY AIM:

Vascular-targeted photodynamic therapy (V-PDT) has been used for several benign vascular diseases. The aim of this pilot study was to demonstrate the potential benefits of VPDT in the treatment of gastric antral vascular ectasia (GAVE).

PATIENTS AND METHODS:

Data from patients with GAVE (n=5) who underwent endoscopic V-PDT were analyzed retrospectively. Pre- and post-V-PDT clinical and endoscopic features, hemoglobin levels, and transfusion requirement were compared.

RESULTS:

The five GAVE patients received one to four sessions of V-PDT. The hemoglobin levels of all five patients increased steadily following V-PDT. Within 6-48months of follow-up, gastrointestinal bleeding and melena disappeared in all five patients and none of the patients needed a transfusion. Endoscopy examinations showed that the dilated vessels had disappeared without scar formation. No significant side effects or adverse reactions were reported.

CONCLUSION:

This preliminary study indicates the good selectivity, safety, and efficacy of V-PDT in the treatment of patients with GAVE. Larger prospective studies are needed to further confirm the feasibility of using V-PDT to treat patients with GAVE.

• Authors: Haixia Qiu, Yongping Mao, Jing Zeng, Ying Wang, Jiaying Zhang, Naiyang Huang, Qingsen Liu, Yunsheng Yang, Enqiang Linghu, Ying Gu
• Journal: Journal of photochemistry and photobiology. B, Biology (J Photochem Photobiol B) Vol. 166 Pg. 58-62 (Jan 2017) ISSN: 1873-2682 [Electronic] Switzerland
• PMID: 27871022 (Publication Type: Journal Article)
• Copyright: Copyright © 2016. Published by Elsevier B.V.

Topics

• Aged
• Female
• Gastric Antral Vascular Ectasia (drug therapy)
• Humans
• Male
• Middle Aged
• Photochemotherapy (adverse effects)
• Pilot Projects
• Retrospective Studies