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T cell line specific for bacterial peptidoglycan subunit: possible role of the COOH-terminal amino acid of the disaccharide tetrapeptide in binding to the T cell receptor.

Abstract
The T cell line specific for a bacterial cell wall peptidoglycan subunit, disaccharide tetrapeptide of diaminopimelic acid type, was examined for epitope specificity in elicitation of delayed-type hypersensitivity (DTH) in X-irradiated Lewis rats, using pairs of analogs different in optical configuration of the COOH-terminal amino acid. The test cell line induced DTH against analogs with the COOH-terminal D-amino acid but not against those with the L-amino acid at the COOH terminus. A close correlation was found between the T cell line-induced DTH reaction in vivo and the proliferative response in vitro, in terms of clear discrimination of the optical configuration of COOH-terminal amino acid of disaccharide tetrapeptide. The L-isomers (non-stimulatory analogs of T cell proliferation) competitively inhibited the proliferation of the T cell line by the corresponding D-isomers. Thus the L-isomers appear to interact with Ia molecules on antigen-presenting cells. We conclude that COOH-terminal D-amino acid of the disaccharide tetrapeptide could be involved in binding to the T cell receptor, induction of T cell proliferation, and elicitation of DTH.
AuthorsM Katsuki, H Iribe, K Kakimoto, S Kotani, S Kawata, T Koga
JournalCellular immunology (Cell Immunol) Vol. 121 Issue 2 Pg. 391-7 (Jul 1989) ISSN: 0008-8749 [Print] UNITED STATES
PMID2786764 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amino Acids
  • Peptidoglycan
  • Receptors, Antigen, T-Cell
Topics
  • Amino Acids (immunology)
  • Animals
  • Cell Line
  • Female
  • Hypersensitivity, Delayed (etiology)
  • Lymphocyte Activation
  • Peptidoglycan (immunology)
  • Rats
  • Rats, Inbred Lew
  • Receptors, Antigen, T-Cell (metabolism)
  • Stereoisomerism
  • T-Lymphocytes (immunology)

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