Abstract | OBJECTIVE: METHODS: 30 OLETF rats served as research subjects and 18 LETO rats of the same strain served as the control group (LETO group). After the first oral glucose tolerance test (at 8-week-old), 6 rats were randomly killed from each group. The remaining 24 OLETF rats were randomly divided into untreated group (OLETF group) and treated group (OLETF/M group, cured with metformin). By the end of the 10th and 20th week of treatment, MTP in the liver was measured for all rats in the study. RESULTS: All OLETF rats exhibited diabetic phenotypes at 18-week-old, with their triglyceride level higher than in LETO rats at the same age. In OLETF rats, MTP level in the liver was higher than in LETO rats at 18-week-old, and the difference was significant at 28-week-old [(13.79±1.47) vs. (8.20±1.14), p<0.05]. Treatment with metformin for 20weeks decreased triglyceride [(1.06±0.23) vs. (2.20±0.62) mmol/L, p<0.05] and total cholesterol [(1.90±0.19) vs. (2.36±0.14) mmol/L, p<0.05] in OLETF rats. Metformin also decreased MTP level in the liver [(7.65±1.31) vs. (13.79±1.47), p<0.01]. CONCLUSIONS:
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Authors | Nianhong Wang, Junqing Zhang, Yiming Wu, Jia Liu, Lin Liu, Xiaohui Guo |
Journal | Diabetes research and clinical practice
(Diabetes Res Clin Pract)
Vol. 122
Pg. 170-178
(Dec 2016)
ISSN: 1872-8227 [Electronic] Ireland |
PMID | 27865164
(Publication Type: Journal Article)
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Copyright | Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Carrier Proteins
- Hypoglycemic Agents
- microsomal triglyceride transfer protein
- Metformin
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Topics |
- Animals
- Blotting, Western
- Carrier Proteins
(biosynthesis, drug effects)
- Diabetes Mellitus, Experimental
(drug therapy, metabolism)
- Diabetes Mellitus, Type 2
(drug therapy, metabolism)
- Hypoglycemic Agents
(therapeutic use)
- Lipid Metabolism
(drug effects)
- Lipid Metabolism Disorders
(drug therapy, genetics, metabolism)
- Male
- Metformin
(therapeutic use)
- Rats
- Rats, Inbred OLETF
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