36-month data for the AdVance XP® male sling: results of a prospective multicentre study.

Abstract

OBJECTIVES:

To evaluate the efficacy and safety of the AdVance XP® sling (Boston Scientific, formerly American Medical Systems) in male stress urinary incontinence (SUI) after radical prostatectomy in a prospective multicentre study, as in recent years several studies have shown the effectiveness and safety of the AdVance sling for treating male SUI and in 2010 the second-generation AdVance XP was introduced with several changes in the sling design and a new needle shape.

PATIENTS AND METHODS:

In all, 115 patients were included. Patients with nocturnal UI, previous UI surgery, previous radiotherapy and a coaptive zone of <1 cm in the preoperative repositioning test were excluded. Postoperatively, a standardised 24-h pad test, quality-of-life scores [International Quality of Life score (IQOL) and International Consultation on Incontinence Questionnaire short form (ICIQ-UI SF)], visual analogue scale (VAS) for pain, five-item version of the International Index of Erectile Function (IIEF-5), International Prostate Symptom Score (IPSS) and Patient Global Impression of Improvement (PGI-I) score, were performed. All patients with a 0-5 g pad test were defined as cured and improved with a reduction of urine loss of >50%. All others were classified as failures. Significance analysis was performed using the Wilcoxon test.

RESULTS:

The mean (median) preoperative urine loss in the 24-h pad test was 272.0 (272.0) g. After a follow-up of 3 months (114 patients), 64.9% of the patients were cured and 31.6% had an improved continence status. The mean urine loss decreased significantly to 34.9 g (P < 0.001), with a mean VAS score of 0.5, and mean PGI-I of 1.5. After a follow-up of 24 months (80 patients), 68.8% of the patients were cured and 22.5% had improved. The mean urine loss decreased significantly to 19.1 g (P < 0.001), with a mean VAS score of 0.3, and mean PGI-I of 1.5. After a follow-up of 36 months (47 patients), 66.0% of the patients were cured and 23.4% had improved. The mean urine loss decreased significantly to 21.8 g (P < 0.001), with a mean VAS score of 0.0, and mean PGI-I of 1.6. The mean IQOL and ICIQ-UI SF improved significantly (both P < 0.001) after 36 months. There were no significant postoperative changes in IIEF-5 and IPSS. No intraoperative and no long-term complications occurred. No erosion or explanations occurred.

CONCLUSION:

The AdVance XP shows good and stable effectiveness and low complication rates even at a mid-term follow-up of up to 36 months.

• Authors: Ricarda M Bauer, Markus T Grabbert, Benedikt Klehr, Peter Gebhartl, Christian Gozzi, Roland Homberg, Florian May, Peter Rehder, Christian G Stief, Alexander Kretschmer
• Journal: BJU international (BJU Int) Vol. 119 Issue 4 Pg. 626-630 (04 2017) ISSN: 1464-410X [Electronic] England
• PMID: 27862836 (Publication Type: Journal Article, Multicenter Study, Observational Study)
• Copyright: © 2016 The Authors BJU International © 2016 BJU International Published by John Wiley & Sons Ltd.

Topics

• Aged
• Aged, 80 and over
• Equipment Design
• Humans
• Male
• Middle Aged
• Postoperative Complications (physiopathology, surgery)
• Prospective Studies
• Prostatectomy (adverse effects)
• Prostatic Neoplasms (physiopathology, surgery)
• Quality of Life
• Suburethral Slings
• Treatment Outcome
• Urinary Incontinence, Stress (etiology, physiopathology, surgery)