Abolishment of metastasis formation by murine tumor cells transfected with "foreign" H-2K genes.

Abstract

High metastatic, low immunogenic Lewis lung carcinoma clones express low levels of H-2Kb major histocompatibility complex antigens. These cells metastasize spontaneously in mice with C57BL/6 genetic background possessing the H-2Db locus. Transfection of different H-2K genes abrogates metastasis in H-2K, H-2D compatible mice and in C57BL/6 recipients. The transfected cells are potent inducers of H-2K-restricted and alloreactive cytotoxic lymphocytes that kill H-2K-positive cells and cross-react with parental nontransfected cells.

• Authors: C Gelber, D Plaksin, E Vadai, M Feldman, L Eisenbach
• Journal: Cancer research (Cancer Res) Vol. 49 Issue 9 Pg. 2366-73 (May 01 1989) ISSN: 0008-5472 [Print] United States
• PMID: 2784997 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• H-2 Antigens

Topics

• Animals
• Cross Reactions
• H-2 Antigens (analysis, genetics, immunology)
• Immunization
• Mice
• Mice, Inbred C57BL
• Neoplasm Metastasis
• Neoplasms, Experimental (immunology)
• T-Lymphocytes, Cytotoxic (immunology)
• Transfection