Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties.

Abstract

Several ribonucleoside analogues with modifications in the nucleobase and sugar moiety have been screened for anti-glioma activity in the T98G glioma cell line using cervical (HeLa) cell line as reference human malignant cells, and lung fibroblast (MCR-5) cell line as non-cancerous reference cells. Among the investigated compounds, ribonucleosides containing 6-chloropurine (3), 7-guanine (5) and a pyrrolopyrimidine (18) as nucleobases, show promising anti-glioma activity with good selectivity indices, and can be considered as lead structures for further anti-cancer studies.

• Authors: Grzegorz Framski, Dariusz Wawrzyniak, Zofia Jahnz-Wechmann, Agnieszka Szymanska-Michalak, Adam Kraszewski, Jan Barciszewski, Jerzy Boryski, Jacek Stawinski
• Journal: Acta biochimica Polonica (Acta Biochim Pol) Vol. 63 Issue 4 Pg. 765-771 ( 2016) ISSN: 1734-154X [Electronic] Poland
• PMID: 27830840 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Furans
• Guanosine
• Cytidine
• Adenosine

Topics

• Adenosine (analogs & derivatives, pharmacology)
• Antineoplastic Agents (pharmacology)
• Brain Neoplasms (drug therapy)
• Cytidine (analogs & derivatives, pharmacology)
• Drug Screening Assays, Antitumor
• Furans (pharmacology)
• Glioblastoma (drug therapy)
• Guanosine (analogs & derivatives, pharmacology)
• HeLa Cells
• Humans
• Inhibitory Concentration 50