[Loco-regional cancer chemotherapy with a new drug delivery system, "anticancer drug-fibrin clot"].

Abstract

Five different types of anticancer drugs were individually entrapped into fibrin clots using our own material, "G.T.XIII" to provide an "anticancer drug-fibrin clot" for regional cancer chemotherapy. Anticancer drugs used in the present study were ADM, MMC, MTX, 5-FU and cDDP. The release of drugs from fibrin clots was studied in vitro. Each fibrin clot was intraperitoneally administered to cancer (AH-130)-bearing rats to evaluate the oncolytic effects. The activities of anticancer drugs delivered from the clots were maintained for more than two weeks. Survival terms of cancer bearing rats were remarkably prolonged with the anticancer drug-fibrin clots. Neither recurrence of ascites nor metastases of malignant cells was observed in the rats treated with such clots. Our newly devised anticancer drug-fibrin clots showed a sustained release of oncolytic drugs and favorable antineoplastic effects. This newly devised drug delivery system suggested a clinical potential for regional cancer chemotherapy.

• Authors: A Sugitachi, Y Takatsuka, N Numata, T Kawahara, M Hirata, T Kido, I Sakamoto
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 16 Issue 8 Pt 2 Pg. 2814-7 (Aug 1989) ISSN: 0385-0684 [Print] Japan
• PMID: 2782891 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Delayed-Action Preparations
• G-T-XIII
• Fibrin
• Factor XIII
• Thrombin

Topics

• Animals
• Antineoplastic Agents (administration & dosage, pharmacokinetics, therapeutic use)
• Delayed-Action Preparations
• Factor XIII (therapeutic use)
• Fibrin (therapeutic use)
• Liver Neoplasms, Experimental (drug therapy, metabolism)
• Male
• Prognosis
• Rats
• Rats, Inbred Strains
• Thrombin (therapeutic use)
• Tissue Distribution