Proteomics progresses in microbial physiology and clinical antimicrobial therapy.

Abstract

Clinical microbial identification plays an important role in optimizing the management of infectious diseases and provides diagnostic and therapeutic support for clinical management. Microbial proteomic research is aimed at identifying proteins associated with microbial activity, which has facilitated the discovery of microbial physiology changes and host-pathogen interactions during bacterial infection and antimicrobial therapy. Here, we summarize proteomic-driven progresses of host-microbial pathogen interactions at multiple levels, mass spectrometry-based microbial proteome identification for clinical diagnosis, and antimicrobial therapy. Proteomic technique progresses pave new ways towards effective prevention and drug discovery for microbial-induced infectious diseases.

• Authors: B Chen, D Zhang, X Wang, W Ma, S Deng, P Zhang, H Zhu, N Xu, S Liang
• Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (Eur J Clin Microbiol Infect Dis) Vol. 36 Issue 3 Pg. 403-413 (Mar 2017) ISSN: 1435-4373 [Electronic] Germany
• PMID: 27812806 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Bacterial Agents
• Proteome

Topics

• Anti-Bacterial Agents (therapeutic use)
• Bacteria (chemistry, classification, isolation & purification, pathogenicity)
• Bacterial Infections (diagnosis, drug therapy)
• Bacteriological Techniques (methods)
• Diagnostic Tests, Routine (methods)
• Host-Pathogen Interactions
• Humans
• Proteome (analysis)
• Proteomics (methods, trends)