Caffeoyl Triterpenoid Esters as Potential Anti-ischemic Stroke Agents from Celastrus orbiculatus.

Abstract

Three new triterpenoids, celastrusins A-C (1-3), together with 3-O-caffeoyl-α-amyrin (4) were isolated from the root bark of Celastrus orbiculatus. Their structures were identified by spectroscopic analysis, X-ray crystallography using Cu Kα radiation, and the comparison of both observed and reported spectroscopic data. An in vitro bioassay revealed that the caffeoyl triterpenoid esters 1, 3, and 4 possess neuroprotective effects against oxygen-glucose deprivation (OGD) induced SH-SY5Y cell damage. Further animal studies indicated that compound 1 significantly reduced brain infarction after transient middle cerebral artery occlusion (MCAO) in rats using a 10 mg/kg (i.v.) dose.

• Authors: Jin-Long Li, Lei Wu, Jian Wu, Hong-Xuan Feng, Hong-Min Wang, Yan Fu, Ru-Jun Zhang, Hai-Yan Zhang, Wei-Min Zhao
• Journal: Journal of natural products (J Nat Prod) Vol. 79 Issue 11 Pg. 2774-2779 (11 23 2016) ISSN: 1520-6025 [Electronic] United States
• PMID: 27791375 (Publication Type: Journal Article)

Chemical References

• Caffeic Acids
• Drugs, Chinese Herbal
• Esters
• Neuroprotective Agents
• Triterpenes
• celastrusin A
• celastrusin B
• celastrusin C
• Oleanolic Acid
• beta-amyrin

Topics

• Animals
• Caffeic Acids (chemistry, isolation & purification, pharmacology)
• Celastrus (chemistry)
• Cerebral Arterial Diseases (drug therapy)
• Crystallography, X-Ray
• Dose-Response Relationship, Drug
• Drugs, Chinese Herbal (chemistry, isolation & purification, pharmacology)
• Esters
• Humans
• Ischemia (drug therapy)
• Male
• Molecular Conformation
• Molecular Structure
• Neuroprotective Agents (chemistry, isolation & purification, pharmacology)
• Nuclear Magnetic Resonance, Biomolecular
• Oleanolic Acid (analogs & derivatives)
• Plant Bark (chemistry)
• Plant Roots (chemistry)
• Rats
• Triterpenes (chemistry, isolation & purification, pharmacology)