Incidence and physiological mechanism of carboplatin-induced electrolyte abnormality among patients with non-small cell lung cancer.

Abstract

To clarify the association between carboplatin and electrolyte abnormality, a pooled-analysis was performed with the adverse event reports of non-small cell lung cancer patients. A total of 19901 adverse events were retrieved from the FDA Adverse Event Reporting System (FAERS). Pooled reporting odds ratios (RORs) and 95% CIs suggested that carboplatin was significantly associated with hyponatremia (pooled ROR = 1.57, 95% CI 1.18-2.09, P = 1.99×10-3) and hypokalemia (pooled ROR = 2.37, 95% CI 1.80-3.10, P = 5.24×10-10) as compared to other therapies. In addition, we found that dehydration was frequently concurrent with carboplatin therapy (pooled ROR = 2.01, 95% CI 1.52-2.66, P = 8.37×10-7), which may prompt excessive water ingestion and decrease serum electrolyte concentrations. This information has not been mentioned in the FDA-approved drug label and could help explain the physiological mechanism of carboplatin-induced electrolyte abnormality. In conclusion, the above results will facilitate clinical management and prompt intervention of life-threatening electrolyte imbalance in the course of cancer treatment.

• Authors: Yushui Ma, Likun Hou, Fei Yu, Gaixia Lu, Shanshan Qin, Ruting Xie, Huiqiong Yang, Tingmiao Wu, Pei Luo, Li Chai, Zhongwei Lv, Xiaodong Peng, Chunyan Wu, Da Fu
• Journal: Oncotarget (Oncotarget) Vol. 8 Issue 11 Pg. 18417-18423 (Mar 14 2017) ISSN: 1949-2553 [Electronic] United States
• PMID: 27780935 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Carboplatin

Topics

• Antineoplastic Agents (administration & dosage, adverse effects)
• Carboplatin (administration & dosage, adverse effects)
• Carcinoma, Non-Small-Cell Lung (drug therapy, metabolism, pathology)
• Drug-Related Side Effects and Adverse Reactions
• Humans
• Hypokalemia (chemically induced)
• Hyponatremia (chemically induced)
• Lung Neoplasms (drug therapy, metabolism, pathology)
• United States
• United States Food and Drug Administration
• Water-Electrolyte Imbalance (blood, chemically induced)