METHODS: The study was carried out using 1475 participants from the Center for Physical Examination, 306 Hospital of PLA in Beijing, China. Fasting blood samples were collected and serum concentrations of 25(
OH)D, total
cholesterol (TC),
triglyceride (TG),
high density lipoprotein cholesterol (HDL-C) and
low density lipoprotein cholesterol (
LDL-C) were measured. AIP was calculated based on the formula: log [TG/HDL-C]. Multiple linear regression analysis was used to estimate the associations between serum 25(
OH)D and
lipids. The association between the occurrences of
dyslipidemias and
vitamin D levels was assessed by multiple logistic regression analysis. Confounding factors, age and BMI, were used for the adjustment.
RESULTS: The median of serum 25(
OH)D concentration was 47 (27-92.25) nmol/L in all subjects. The overall percentage of 25(
OH)D ≦ 50 nmol/L was 58.5% (males 54.4%, females 63.7%). The serum 25(
OH)D levels were inversely associated with TG (β coefficient = -0.24, p < 0.001) and
LDL-C (β coefficient = -0.34, p < 0.001) and positively associated with TC (β coefficient = 0.35, p < 0.002) in men. The associations between serum 25(
OH)D and
LDL-C (β coefficient = -0.25, p = 0.01) and TC (β coefficient = 0.39, p = 0.001) also existed in women. The serum 25(
OH)D concentrations were negatively associated with AIP in men (r = -0.111, p < 0.01) but not in women. In addition,
vitamin D deficient men had higher AIP values than
vitamin D sufficient men. Furthermore, the occurrences of
dyslipidemias (reduced HDL-C, elevated TG and elevated AIP) correlated with lower 25(
OH)D levels in men, whereas the higher TC and
LDL-C associated with higher 25(
OH)D levels in women.
CONCLUSION: