Concanavalin A--horse radish peroxidase (Con A-HRP) labelling technique in detection and prognosis of cancer of uterine cervix.

Abstract

The lectin binding capacity of the exfoliated epithelial cells of the uterine cervix was investigated with a modified concanavalin A - horse radish peroxidase labelling procedure. The normal healthy females exhibited a distinct rise in the percentage of labelled cells in comparison to those bearing squamous cell carcinoma. In the treated group, the responsive patients again exhibited a higher labelling percentage than the non-responsive patients - showing that the method is of both diagnostic and prognostic significance.

• Authors: U Sen
• Journal: European journal of gynaecological oncology (Eur J Gynaecol Oncol) Vol. 10 Issue 4 Pg. 289-91 ( 1989) ISSN: 0392-2936 [Print] Singapore
• PMID: 2776788 (Publication Type: Journal Article)

Chemical References

• concanavalin A-horseradish peroxidase conjugate
• Concanavalin A
• Horseradish Peroxidase
• Peroxidases

Topics

• Adult
• Cells, Cultured
• Cervix Uteri (cytology)
• Concanavalin A (analogs & derivatives)
• Female
• Follow-Up Studies
• Horseradish Peroxidase
• Humans
• Middle Aged
• Peroxidases
• Tumor Cells, Cultured
• Uterine Cervical Neoplasms (diagnosis)