| Abstract | An immunological study was carried out of 51 patients with pulmonary sarcoidosis. Two groups of patients were singled out: receiving and not receiving glucocorticoid treatment (prednisolone: 0.3 mg/kg of body weight). It was found that patients with pulmonary sarcoidosis revealed changes of the functional state of neutrophils and monocytes of the peripheral blood manifested in a reduction of their absorptive capacity, number of rosette-forming cells, adhesiveness of neutrophils, increase of oxygen-dependent metabolism, production of lysozyme by neutrophils. Prednisolone treatment effected the state of neutrophils manifested in a reduced acid phosphatase activity; the production of lysozyme increased, the absorptive capacity normalized. |
| Authors | N A Tyshko |
| Journal | Vrachebnoe delo
(Vrach Delo)
Issue 5
Pg. 88-90
(May 1989)
ISSN: 0049-6804 USSR |
| Vernacular Title | Deĭstvie prednizolona na funktsionalnoe sostoianie fagotsitiruiushchikh kletok perfericheskoĭ krovi bol'nykh sarkoidozom legkikh. |
| PMID | 2773446
(Publication Type: English Abstract, Journal Article)
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| Chemical References |
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| Topics |
- Granulocytes
(immunology)
- Humans
- Lung Diseases
(drug therapy, immunology)
- Monocytes
(immunology)
- Phagocytosis
- Prednisolone
(pharmacology)
- Sarcoidosis
(drug therapy, immunology)
|
