Aidi injection combined with CHOP chemotherapy regimen in the treatment of malignant lymphoma: A meta-analysis based on randomized controlled trials.

Abstract

OBJECTIVE:

The aim of this study was to evaluate the clinical efficacy of Aidi injection combined with CHOP chemotherapy regimen in the treatment of malignant lymphoma.

METHODS:

We made an electronic search in the database of Wanfang, CNKI, and PubMed. All the clinical studies related to Aidi injection combined with CHOP chemotherapy regimen in the treatment of malignant lymphoma were screened and reviewed. The combined objective response rate (ORR), life quality improvement, and hematological toxicity were pooled by random- or fixed-effect model according to the heterogeneity across the included study. Moreover, the publication bias was evaluated by Begg's funnel plot and Egger's line regression test.

RESULTS:

Eight prospective clinical trials with 513 subjects (273 in the Aidi injection plus CHOP group and 240 in the CHOP group) were included in this meta-analysis. The pooled results showed that Aidi injection combined with CHOP chemotherapy regimen can significantly improve the ORR (odds ratio [OR] =1.68, 95% confidence interval [CI]: 1.09-2.60, P < 0.05), improve the life quality (OR = 3.32, 95% CI: 1.97-5.58, P < 0.05), and decrease the risk of developing leukopenia (OR = 0.25, 95% CI: 0.17-0.39, P < 0.05) and thrombocytopenia (OR = 0.34, 95% CI: 0.22-0.53, P < 0.05).

CONCLUSION:

With the present evidence, Aidi injection combined with CHOP chemotherapy regimen can improve the treatment response and quality of life and decrease the risk of developing severe leukopenia or thrombocytopenia.

• Authors: Xiaoli Wang, Weimei Jin, Bingmu Fang, Jinhong Jiang, Min Liu, Yifen Lan, Zhigang Qu, Guangli Ma, Yu Jiang, Yonghua Liu, Yuxiao Zeng, Xiaoqiu Wang
• Journal: Journal of cancer research and therapeutics (J Cancer Res Ther) Vol. 12 Issue Supplement Pg. 11-14 (Oct 2016) ISSN: 1998-4138 [Electronic] India
• PMID: 27721243 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Drugs, Chinese Herbal
• aidi herbal drug
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisone

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cyclophosphamide (therapeutic use)
• Doxorubicin (therapeutic use)
• Drugs, Chinese Herbal (administration & dosage)
• Humans
• Lymphoma (drug therapy)
• Odds Ratio
• Prednisone (therapeutic use)
• Quality of Life
• Randomized Controlled Trials as Topic
• Treatment Outcome
• Vincristine (therapeutic use)