Abstract |
Five patients with severe dysthyroid optic neuropathy were treated with intravenous methylprednisolone (1 g daily for 3 consecutive days). Before administration, visual acuity of the more severely affected eyes of each patient was counting fingers at 5 feet, 8/200, 20/400, 20/200, and 20/80. Immediately after completion of pulse therapy, visual acuity improved to 20/25 in four patients and 20/30 in one. Remissions were maintained with oral prednisone and external beam irradiation of the orbit. Pulse methylprednisolone therapy appears to be beneficial in the initial management of severe dysthyroid optic neuropathy.
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Authors | J R Guy, S Fagien, J P Donovan, M L Rubin |
Journal | Ophthalmology
(Ophthalmology)
Vol. 96
Issue 7
Pg. 1048-52; discussion 1052-3
(Jul 1989)
ISSN: 0161-6420 [Print] United States |
PMID | 2771352
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hydrochlorothiazide
- Methylprednisolone
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Topics |
- Adult
- Female
- Graves Disease
(drug therapy)
- Humans
- Hydrochlorothiazide
(administration & dosage)
- Hypertension
(drug therapy)
- Injections, Intravenous
- Magnetic Resonance Imaging
- Male
- Methylprednisolone
(therapeutic use)
- Middle Aged
- Orbit
(radiation effects)
- Tomography, X-Ray Computed
- Visual Acuity
- Visual Fields
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