Perioperative mortality is the Achilles heel for cardiac transplantation in adults with congenital heart disease: Evidence from analysis of the UNOS registry.

Abstract

BACKGROUND:

Adults with congenital heart disease may present with end-stage heart failure necessitating orthotopic heart transplant (OHT). We sought to review the United Network for Organ Sharing (UNOS) experience with this unique cohort focusing on surgical outcomes and survival.

METHODS:

From the UNOS registry, 737 adult congenital heart disease recipients (ACHDR) out of 26,993 OHT patients (2.7%) who underwent OHT were studied to analyze early and late outcomes and compared to non-congenital recipients (NCR) over a 15-year period (2000-2014).

RESULTS:

More ACHDR underwent OHT in the recent-era (3.1%; 2010-2014) as compared to the initial-era (2.5%; 2000-2004; p = 0.03). ACHDR were more likely female (40% vs. 24%; p < 0.01), younger (35 vs. 53 years; p < 0.01), less likely to have ventricular assist devices (4.2% vs. 19.3%; p < 0.01), more likely to have class-II panel-reactive antibody >10%; p < 0.01, and were listed for a longer time (249 vs. 181 days; p < 0.01). When compared to the NCR in the same period, the ACHDR cohort had longer postoperative length of stay (27 vs. 20 days; p < 0.01), higher operative mortality (11.5% vs. 4.6% p < 0.001), higher incidence of primary graft dysfunction (4.3% vs. 2.6%; p < 0.01), and higher need for dialysis (20% vs. 9%; p < 0.01). Primary graft dysfunction is the most common cause of death in (5.8%) ACHDR. Although short-term survival is poorer, long-term survival of ACHDR was found to be equivalent or better than NCR in long term.

CONCLUSIONS:

Perioperative morbidity and mortality adversely affects short-term survival in ACHDR. ACHDR who survive the first post-transplant year have equivalent or better long-term survival than NCR.

• Authors: Dipesh K Shah, Salil V Deo, Andrew D Althouse, Jeffery J Teuteberg, Soon J Park, Robert L Kormos, Harold M Burkhart, Victor O Morell
• Journal: Journal of cardiac surgery (J Card Surg) Vol. 31 Issue 12 Pg. 755-764 (Dec 2016) ISSN: 1540-8191 [Electronic] United States
• PMID: 27709686 (Publication Type: Journal Article)
• Copyright: © 2016 Wiley Periodicals, Inc.

Topics

• Adult
• Age Factors
• Aged
• Cohort Studies
• Female
• Heart Defects, Congenital (complications)
• Heart Failure (etiology, surgery)
• Heart Transplantation (mortality)
• Heart-Assist Devices (statistics & numerical data)
• Humans
• Length of Stay (statistics & numerical data)
• Male
• Middle Aged
• Perioperative Period
• Primary Graft Dysfunction (epidemiology)
• Registries (statistics & numerical data)
• Sex Factors
• Survival Rate
• Time Factors
• Tissue and Organ Procurement (statistics & numerical data)
• Treatment Outcome