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Prelabeled red nucleus and sensorimotor cortex neurons of the rat survive 10 and 20 weeks after spinal cord transection.

Abstract
To demonstrate definitively the fate of the somata of rubrospinal and corticospinal neurons axotomized by a complete spinal cord transection at T-9, in young adult rats we prelabeled the neurons by injection into the lumbar enlargement of a retrogradely transported fluorescent dye, Fluoro-Gold, and four days later transected the cord. We found no loss in cell number ten or 20 weeks after axotomy. The average size of the neurons in each case is slightly but significantly reduced. These findings unequivocally demonstrate that the somata of long tract neurons of the rubrospinal and corticospinal systems persist in an atrophic and presumably inactive state for at least 20 weeks, and raise the possibility that treatment of spinal cord injury may normalize cell activity and allow long tract regeneration.
AuthorsR L McBride, E R Feringa, M K Garver, J K Williams Jr
JournalJournal of neuropathology and experimental neurology (J Neuropathol Exp Neurol) Vol. 48 Issue 5 Pg. 568-76 (Sep 1989) ISSN: 0022-3069 [Print] England
PMID2769309 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • 2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt
  • Fluorescent Dyes
  • Stilbamidines
  • Horseradish Peroxidase
Topics
  • Animals
  • Cell Survival
  • Denervation
  • Female
  • Fluorescent Dyes
  • Horseradish Peroxidase
  • Mice
  • Mice, Inbred Strains
  • Motor Cortex (cytology)
  • Neurons (physiology)
  • Red Nucleus (cytology)
  • Somatosensory Cortex (cytology)
  • Spinal Cord (physiology)
  • Stilbamidines

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