Abstract | BACKGROUND: The dopamine system plays a key role in motor learning and neuroplasticity. Several studies have studied the efficacy of dopaminergic drugs in enhancing motor recovery after stroke, but the effects are controversial. Although genetic variations in plasticity-related genes influence each individual's capacity for recovery after stroke, limited studies have investigated the effects of polymorphism of dopamine-related genes. OBJECTIVE: METHODS: We enrolled 74 patients with first-ever stroke (42 males, 32 females, mean age: 61.4±14.1 y). During admission, blood samples were collected, and the genotypes of COMT, DRD1, DRD2, and DRD3 were analyzed. The primary outcome was assessed with Fugl-Meyer Assessment (FMA) at 1 week, 3 months, and 6 months after stroke; secondary outcomes were assessed with Functional Independence Measure (FIM) and mini-mental state examination at 3 and 6 months after stroke. The association between polymorphisms and functional outcome was analyzed. RESULTS: There were no significant associations between COMT polymorphisms and FMA or FIM scores at 1 week after stroke or between DRD1, DRD2, or DRD3 genotypes and FMA or FIM scores at any point. COMT genotypes were significantly associated with FMA and FIM at 3 months (p < 0.01 and p < 0.05, respectively) and at 6 months (p < 0.01 and p < 0.05, respectively). CONCLUSION: These data suggest that genetic variation of dopamine-related genes may affect motor recovery after stroke and that COMT polymorphism could be useful for predicting motor recovery.
|
Authors | Bo-Ram Kim, Hahn Young Kim, Young Il Chun, Yeo-Min Yun, Hyuntae Kim, Dong-Hee Choi, Jongmin Lee |
Journal | Restorative neurology and neuroscience
(Restor Neurol Neurosci)
Vol. 34
Issue 6
Pg. 925-934
(11 22 2016)
ISSN: 1878-3627 [Electronic] Netherlands |
PMID | 27689550
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Receptors, Dopamine
- Catechol O-Methyltransferase
|
Topics |
- Adult
- Aged
- Catechol O-Methyltransferase
(genetics)
- Female
- Gene Frequency
- Genetic Association Studies
- Genotype
- Humans
- Male
- Middle Aged
- Movement
(physiology)
- Neuropsychological Tests
- Polymorphism, Single Nucleotide
(genetics)
- Receptors, Dopamine
(genetics)
- Retrospective Studies
- Stroke
(complications, genetics)
|