Sustained-release verapamil as a first-step drug in the treatment of mild to moderate hypertension.

The efficacy of sustained-release verapamil as a first-stage treatment for mild to moderate, uncomplicated essential hypertension was studied. Nineteen patients aged 36-70 years (mean +/- SD 55 +/- 10 years) entered the study. Treatment with 240 mg sustained-release verapamil, once daily for 8 weeks, caused systolic and diastolic blood pressures to decline significantly during the first 2 weeks and this lower level was maintained until week 8. Heart rate decreased gradually during the treatment period reaching significance at week 8. After 2 weeks maximum systolic and diastolic blood pressures during isometric exercise were significantly reduced compared with pre-treatment values; there was no difference in the percentage increase occurring pre- and post-treatment. These measures for heart rate did not change significantly. Except for a significant reduction in cardiac index after 8 weeks left ventricular function and left ventricular mass were unchanged. The 24-h urinary Na+ excretion increased significantly after 2 and 8 weeks' treatment. Plasma renin activity, serum lipid concentrations and routine blood chemistries were not affected. Side-effects were transient and did not require discontinuation of therapy. In conclusion, sustained-release verapamil is an efficacious and well tolerated first-stage drug in the treatment of essential hypertension.
AuthorsS M Karcier, B Orbay, A B Ozder, N Gürses, S Aytekin, S Satar, M Oztürk, C Demiroğlu
JournalThe Journal of international medical research (J Int Med Res) 1989 May-Jun Vol. 17 Issue 3 Pg. 268-76 ISSN: 0300-0605 [Print] ENGLAND
PMID2767329 (Publication Type: Journal Article)
Chemical References
  • Delayed-Action Preparations
  • Verapamil
  • Blood Pressure (drug effects)
  • Delayed-Action Preparations
  • Electrocardiography
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Hypertension (drug therapy, physiopathology)
  • Isometric Contraction
  • Male
  • Middle Aged
  • Physical Exertion
  • Verapamil (therapeutic use)

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