[Bone quality in COPD.]

Abstract

Chronic obstructive pulmonary disease(COPD)is a chronic inflammatory disease associated with an increase of fracture risk. Bone strength is determined by bone mass and quality.Bone quality is thought to encompass the structural and material properties of bone. Bone collagen crosslinking plays important roles in bone strength. The quantitative and qualitative deterioration of lysyl oxidase control and non enzymatic cross-links(advanced glycation end products, AGEs, pentosidine)of collagen in patients with osteoporotic femoral neck fracture and diabetes, and COPD might be affected by increased oxidative stress and glycation.

• Authors: Mitsuru Saito, Keishi Marumo
• Journal: Clinical calcium (Clin Calcium) 2016 Vol. 26 Issue 10 Pg. 1437-1444 ISSN: 0917-5857 [Print] Japan
• PMID: 27666691 (Publication Type: Journal Article, Review)

Chemical References

• Collagen

Topics

• Animals
• Bone Density (physiology)
• Bone and Bones (metabolism)
• Collagen (metabolism)
• Humans
• Osteoporosis (complications, etiology, metabolism)
• Pulmonary Disease, Chronic Obstructive (complications, metabolism)
• Risk Factors