[The effect of metipamide on levels of sodium and potassium in erythrocytes].

Abstract

The effect of metipamide on the level of Na+ and K+ in erythrocytes was studied in patients with essential hypertension. The control series consisted of healthy normotonics. In normotonics Nai+ and Ki+ were not affected in vitro, whereas in hypertonics Nai+ was found to be significantly increased (p less than 0.01) and Ki+ decreased (p less than 0.025). In vivo two subgroups of hypertonics were established: a) hypertonics with normal content of Nai+ (6.9 +/- 0.3.10(-3) mol/l) and b) hypertonics with increased content of Nai+ (9.2 +/- 0.3.10(-3) mol/l compared to 7.3 +/- 0.1.10(-3) mol/l, p less than 0.005). With respect to the given heterogeneity of the series, the response to metipamide treatment failed to be uniform. A part of the patients responded to therapy by diminished Nai+, manifesting one of the potential mechanisms of the antihypertensive effect of metipamide. The significant drop of Ki+ recorded in both subgroups of patients in the course of treatment demonstrated the potassium depleting effect of the drug.

• Authors: M Molitorisová, K Sedláková, R Dzúrik
• Journal: Bratislavske lekarske listy (Bratisl Lek Listy) Vol. 90 Issue 4 Pg. 294-9 (Apr 1989) ISSN: 0006-9248 [Print] Slovakia
• Vernacular Title: Ucinok metipamidu na koncentráciu sodíka a draslíka v erytrocytoch.
• PMID: 2765961 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antihypertensive Agents
• Diuretics
• metipamide
• Sodium
• Indapamide
• Potassium

Topics

• Adult
• Aged
• Antihypertensive Agents (pharmacology)
• Diuretics (pharmacology)
• Erythrocytes (metabolism)
• Female
• Humans
• Hypertension (blood)
• In Vitro Techniques
• Indapamide (analogs & derivatives, pharmacology)
• Male
• Middle Aged
• Potassium (blood)
• Sodium (blood)