Detection and study of plasma D-dimer change in patients with acute exacerbation of chronic obstructive pulmonary disease.

Abstract

The purpose of this study was to observe the change in plasma D-dimer of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The patients were divided into three groups, i.e., AECOPD group, stable COPD group (COPD kept stable after treatment) and a healthy control group. The content of plasma fibrinogen (FIB) and D-dimer of all research subjects was detected and the difference between groups was analyzed. Moreover, pulmonary functions of patients in the AECOPD group and the stable COPD group, including forced expiratory volume in 1 second (FEV1%) and forced vital capacity rate of 1 second (FEV1/FVC), and blood gas (oxygen partial pressure (PO2) and partial pressure of carbon dioxide (PaCO2), were detected; and the differences between the two groups and the possible correlation were analyzed. Compared to the COPD stable group and the control group, the AECOPD group had a statistically significant higher content of plasma FIB and D-dimer (p less than 0.05); the content of plasma FIB and D-dimer of the COPD stable group was much higher than that of the healthy control group, but the difference had no statistical significance (p > 0.05); the content of D-dimer of AECOPD patients was in a negative correlation with FEV1 and PO2 (p smaller than 0.05) and in a positive correlation with PCO2 (p smaller than 0.05). It can be concluded that D-dimer is correlated to the severity of AECOPD; hence, it can be used as an evaluation index for the severity of AECOPD.

• Authors: B H Liu, M X Sun, N Zhou, Y P Li, M Z Wang, J Yu, H S Zhou
• Journal: Journal of biological regulators and homeostatic agents (J Biol Regul Homeost Agents) 2016 Jul-Sep Vol. 30 Issue 3 Pg. 839-845 ISSN: 0393-974X [Print] Italy
• PMID: 27655508 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Fibrin Fibrinogen Degradation Products
• fibrin fragment D
• Carbon Dioxide
• Fibrinogen
• Oxygen

Topics

• Aged
• Aged, 80 and over
• Carbon Dioxide (blood)
• Disease Progression
• Female
• Fibrin Fibrinogen Degradation Products (analysis)
• Fibrinogen (analysis)
• Forced Expiratory Volume
• Humans
• Male
• Middle Aged
• Oxygen (blood)
• Pulmonary Disease, Chronic Obstructive (blood, physiopathology)
• Severity of Illness Index
• Vital Capacity