[Biotransformation in patients following Depressan-induced hepatitis].

Abstract

In 17 patients who more than 1 year ago had suffered from a dihydralazine induced hepatitis the biotransformation velocity was investigated and compared with a healthy control group. 15 out of the 17 patients and 5 out of the 10 volunteers are slow acetylators. All slow acetylators eliminate sulfamethazine more slowly than rapid acetylators.--The elimination of caffeine and metamizol--test substances for oxidative biotransformation reactions--was retarded in patients after dihydralazine induced hepatitis in comparison to control persons. Slow acetylators have to be controlled carefully because of their higher risk of dihydralazine induced drug hepatitis.

• Authors: A Hoffmann, M Reinhardt, C Rechenbach, L Henschel, D Jorke
• Journal: Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR (Gastroenterol J) Vol. 49 Issue 1 Pg. 8-11 ( 1989) ISSN: 0863-1743 [Print] Germany
• Vernacular Title: Biotransformation bei Patienten nach Depressan-Hepatitis.
• PMID: 2765156 (Publication Type: Journal Article)

Chemical References

• Hydralazine
• Caffeine
• Sulfamethazine
• Dihydralazine

Topics

• Adult
• Aged
• Biotransformation
• Caffeine (pharmacokinetics)
• Chemical and Drug Induced Liver Injury (blood)
• Dihydralazine (adverse effects)
• Female
• Follow-Up Studies
• Humans
• Hydralazine (analogs & derivatives)
• Liver Function Tests
• Male
• Middle Aged
• Sulfamethazine (pharmacokinetics)