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Regulation of expression of avian slow myosin heavy-chain isoforms.

Abstract
The slow tonic anterior latissimus dorsi (ALD) muscle of the chicken contains two isomyosins, namely SM-1 and SM-2. The proportions of the two isoforms change with age, SM-2 expression increasing at the expense of SM-1. Applying a load on the wing increases the rate and extent of SM-1 replacement. Here we have demonstrated that decreasing the load by removal of the distal portion of the wing in 1-week-old chickens had an effect opposite to that of overloading in that it slowed muscle growth and the rate of SM-1 elimination. Experimental unloading of muscles previously weighted for 1 or 3 weeks slowed the growth rate of muscles, with consequent regression of relative hypertrophy; however, it did not lead to the reexpression of SM-1 myosin. This indicates that the overload-induced changes in myosin expression are not readily reversible. Nerve section produced unexpected results, in that it advanced the normal developmental shift in myosin expression toward predominance of the SM-2 isoform, similar to the effect of muscle overload.
AuthorsS K Reid, J M Kennedy, N Shimizu, A Stewart, G Vrbova, R Zak
JournalThe Biochemical journal (Biochem J) Vol. 260 Issue 2 Pg. 449-54 (Jun 01 1989) ISSN: 0264-6021 [Print] England
PMID2764882 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Myosins
Topics
  • Animals
  • Chickens
  • Gene Expression Regulation
  • Isomerism
  • Muscle Denervation
  • Myosins (genetics)

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