Abstract |
Clinical investigations have shown that 1 alpha-hydroxycholecalciferol ( oxydevit, alphacalcidiol) and 1 alpha, 25-dihydroxycholecalciferol ( rocaltrol) are act vitamin D3 agents producing a positive clinical effect in different types of osteoporosis and osteomalacia. Clinical improvement of the patients' status (alleviation of the pain syndrome, an increase in motor activity) was noted in 1-2 mos., an x-ray picture of regeneration of the bone structure of both axial and peripheral skeleton--in 6-12 mos. after the initiation of therapy. Therapy was attended by an increase in the serum content of total and ionized calcium, the return of alkaline phosphatase activity to normal, and a decrease in the level of parathormone. During prolonged therapy these agents administered at daily doses of 0.25-2 micrograms caused no pathological side-effects and hypercalcemia. In osteoporotic conditions all these drugs were equal in their clinical effectiveness. Rocaltrol has some advantages in the presence of associated liver pathology.
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Authors | N A Zarubina, L Ia Rozhinskaia, A I Bukhman, I I Dorokhova, E V Konnova |
Journal | Problemy endokrinologii
(Probl Endokrinol (Mosk))
1989 May-Jun
Vol. 35
Issue 3
Pg. 15-9
ISSN: 0375-9660 [Print] Russia (Federation) |
Vernacular Title | Sravnitel'naia otsenka éffektivnosti preparatov vitamina D3 (1-alpha- i 1-alpha,25-dihydroxycholecalciferol) pri razlichnykh vidakh osteoporoza i osteomaliatsii. |
PMID | 2762260
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Hydroxycholecalciferols
- Parathyroid Hormone
- Phosphorus
- Calcitonin
- Alkaline Phosphatase
- Calcitriol
- Calcium
- alfacalcidol
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alkaline Phosphatase
(blood)
- Calcitonin
(metabolism)
- Calcitriol
(therapeutic use)
- Calcium
(metabolism)
- Child
- Female
- Humans
- Hydroxycholecalciferols
(therapeutic use)
- Male
- Middle Aged
- Osteomalacia
(drug therapy, metabolism)
- Osteoporosis
(drug therapy, metabolism)
- Parathyroid Hormone
(blood)
- Phosphorus
(metabolism)
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