[Use of defibrotide in the treatment of acute superficial thrombophlebitis of the legs].

Abstract

The efficacy of defibrotide in the treatment of acute thrombophlebitis of the legs has been investigated in 140 patients, randomized into two groups. All patients received defibrotide either alone or as an addition to conventional therapies. Two different schemes of administration were selected and carried out in each group, according to the time of onset of thrombophlebitis. Defibrotide demonstrated a good clinical efficacy in both groups, with a highly significant reduction in those patients receiving defibrotide and conventional therapies. The clinical result were outstanding in two subgroups: extensive thrombophlebitis and brachioaxillary phlebitis.

• Authors: M Seccia, P Bortolotti, M G Bellomini, P Buccianti, M Chiarugi, E Cavina
• Journal: Minerva chirurgica (Minerva Chir) Vol. 44 Issue 9 Pg. 1379-84 (May 15 1989) ISSN: 0026-4733 [Print] Italy
• Vernacular Title: Impiego del defibrotide nel trattamento delle tromboflebiti acute superficiali degli arti.
• PMID: 2761740 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Fibrinolytic Agents
• Polydeoxyribonucleotides
• defibrotide

Topics

• Acute Disease
• Adult
• Aged
• Aged, 80 and over
• Drug Evaluation
• Female
• Fibrinolytic Agents (therapeutic use)
• Humans
• Male
• Middle Aged
• Polydeoxyribonucleotides (therapeutic use)
• Random Allocation
• Thrombophlebitis (drug therapy, pathology)
• Time Factors