[Effect of danazol on heterozygous c protein coagulation deficiency exacerbated by Salmonella typhi sepsis].

Abstract

The case of an 8-month-old male with heterozygous coagulation protein C deficiency is presented. Sepsis due to Salmonella typhi aggravated the protein C deficiency and resulted in arterial thrombosis of the distal third of the lower right limb. The patient was treated with both heparin and danazol, the levels of functional protein C increasing and the necrotic phenomenon resolving, thus making unnecessary amputation of the limb. The observation is discussed with the evidences of danazol being useful in the treatment of patients with protein C deficiency.

• Authors: E Lobato-Mendizábal, G J Ruiz-Argüelles, O Toquero-Franco
• Journal: Boletin medico del Hospital Infantil de Mexico (Bol Med Hosp Infant Mex) Vol. 46 Issue 5 Pg. 343-5 (May 1989) ISSN: 0539-6115 [Print] Mexico
• Vernacular Title: Efecto del danazol en deficiencia heterocigota de la proteína C de coagulación agravada por sepsis por Salmonella typhi.
• PMID: 2757777 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Pregnadienes
• Danazol

Topics

• Danazol (therapeutic use)
• Heterozygote
• Humans
• Infant
• Male
• Pregnadienes (therapeutic use)
• Protein C Deficiency
• Protein Deficiency (blood, complications, drug therapy, genetics)
• Typhoid Fever (blood, complications)